Bactericidal chemical agents capable of killing bacteria. Glutaraldehyde is a biocide with broad spectrum of activity including sporicidal activity. Chemical product and company identification product name. Kemsafe powder neutralizer for glutaraldehyde and opa. Antimicrobial efficacy of chemical disinfectants on. Glutaraldehyde is a potent occupational skin irritant glutaraldehyde is a recognized cause of occupational asthma. Guideline for disinfection and sterilization in healthcare. An evaluation of a manual disinfection procedure to eliminate hcv from. Cho, is a transparent oily, liquid with a pungent odor. A stable 2% glutaraldehyde solution that meets all requirements as a superior sterilizingdisinfecting solution. It has bactericidal, tuberculocidal, fungicidal and virucidal properties. Cidex activated glutaraldehyde solution offers excellent materials compatibility and can therefore be used to disinfect a wide range of medical instruments. Best practices for the safe use of glutaraldehyde in health. Use of glutaraldehyde as a disinfectant can cause it to enter water, such as from hospital.
Exposure to glutaraldehyde may cause the following symptoms. Glutaraldehyde solution, grade i, 8% in h 2 o, specially purified for use as an electron microscopy fixative or other sophisticated use, glutaraldehyde solution, for in vitro diagnostic use, glutaraldehyde solution, 50% in h 2 o, suitable for photographic applications. In the laboratory, glutaraldehyde solution is commonly used as an aminereactive homobifunctional crosslinker and as a disinfectant for medical equipment. Liquid and vapor contact when handling glutaraldehydebased solutions, avoid contact with the liquid and. Mechanism of glutaraldehyde disinfectants articles. Glutaraldehyde was developed in the 1960s as an alternative sporicide because of its broad spectrum of activity, its more rapid action, its lack of corrosion to metals, rubbers and plastics and its less volatile nature. The glutaraldehyde and the alcohol ethoxylate nonionic surfactant are chemically bound together. The european suspension test was applied to compare the in vitro activity of three glutaraldehydebased disinfectants. Search results for glutaraldehyde solution at sigmaaldrich. The high level disinfection products metricide, metricide 28, and metricide plus 30 are available in three concentrations of glutaraldehyde, 2. For example, it is used in oil and gas recovery operations and pipelines, waste water treatment, xray processing, embalming fluid, leather tanning.
Identification of the substancemixture and of the companyundertaking product identifier bm28 plus, 2% glutaraldehyde relevant identified uses of the substance or mixture and uses advised against instrument immersion disinfectant details of the supplier of. Glutaraldehyde solution is intended for use in the manual bucket and. As a medication, it is used to treat warts on the bottom of the feet. The contaminated carrier is soaked in the disinfectant solution. Only when the solution is activated made alkaline by use of alkalinizing agents to ph 7.
Its physical state is of a liquid that appears as transparent colorless. Glutaraldehyde is a saturated dialdehyde that has gained wide acceptance as a highlevel disinfectant and chemical sterilant. Do not use glutaraldehyde for surface disinfection osha. Antimicrobial effectiveness of 2% glutaraldehyde versus. Glutaraldehyde solution 2 % exporters, equivalents. Glutaraldehyde is widely used as a disinfectant and sterilising agent usually as a 2% solution in medical and dental settings, in embalming 25% solution, as an. Glutaraldehyde is not stable in its pure form, so it is usually found in a solution mixed with water. Mckesson glutaraldehyde high level disinfectant solution regimen glutaraldehyde solution is used for high level disinfection, or as an alternative method of sterilization when other chemical sterilants are not sufficient. Illness was associated with use of sigmoidoscopes cleaned by one clinic assistant and appeared to be caused by 2% glutaraldehyde disinfectant solution left in the instruments after cleaning. Glutaraldehyde based disinfectant intended use of the product. Glutaraldehyde solution 2 % by nature has sharp, fruity, medicinal. Glutaraldehyde solutions are pale yellow liquids that smell like rotten apples. Ltd it is essentially comprised of glutaraldehyde of cas no. This invention relates to a stabilized aqueous glutaraldehyde solution including 0.
Exposure to glutaraldehyde as a highlevel disinfectant occurs primarily during the following activities. Glutaraldehyde is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment. If this occurs, addition of water to dilute the solution is recommended. Glutaraldehyde is widely used as a disinfectant and sterilising agent usually as a. Glutaraldehyde solution sds msds sheet, suppliers and. High level disinfectants high level disinfection metrex. Sds for td5 1 of 3 200441j section i identification product identification product form. Hospital disinfectants glutaraldehyde solution with. Glutaraldehyde is a colorless, oily liquid with a sharp, pungent odor. Material safety data sheet glutaraldehyde solution, 50% msds section 1. Because of glutaraldehydes toxic nature and corrosive properties, the u. Formalin formalin is a 37% solution of formaldehyde gas in water.
Chemtrec 8004249300 outside usa 7035273887 product identification product name. Pour kemsafe neutralizing powder into container with waste disinfectant solution that you intend to neutralize one container neutralizing powder per 5 gallons waste solution. Glutaraldehyde is a potent and broad spectrum antimicrobial agent which can be used in many animal housing applications. Wholesale supplier of hospital disinfectants glutaraldehyde solution with activator, peracetic acid based disinfectant for hospitals, air and surface disinfectant and aldehyde free medical device sterilant offered by acuro organics limited, new delhi, delhi. Glutaraldehyde, 25% material safety data sheet integra chemical company 1216 6th ave n kent wa 98032 phone. Best practices for the safe use of glutaraldehyde in. Provides complete sterilization or highlevel disinfection of semicritical. Please refer to the instructions provided by the manufacturer of the solution for details. Costcompetitive alternatives exist that meet infection employee health. With customers in 55 countries across 5 continents, we source and sell most chemicals. Glutaraldehyde is used for industrial, laboratory, agricultural, and medical purposes, primarily for. The mechanism of action of glutaraldehyde involves a strong association with the outer layers of bacterial cells, specifically with unprotonated amines on the cell surface, possibly representing the reactive sites. Selection and use of disinfectants christopher lipowski. Agencys revised human health and ecological risk assessments.
Since glutaraldehyde solutions are reused for up to 14 days, with instruments being dipped repeatedly, the solution tends to get diluted and its ph varies over this reuse period therefore, to ensure that your glutaraldehyde disinfectant solution efficiently destroys microorganisms during. Mckesson glutaraldehyde high level disinfectant best. Evaluation of three glutaraldehydebased disinfectants used in. As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals. Glutaraldehyde remains active longer than a typical oxidising biocide. After 5 or 20 minutes contact the disinfectant is neutralized. Dumping used opa or glutaraldehyde down the drain without first deactivating it can be dangerous to you and, in some cases, illegal. Glutaraldehyde is a disinfectant, sanitizer, biocide, fungicide, microbiocide, tuberculocide, and virucide antimicrobial chemical.
The overall results on all microorganisms in 20 minutes, show similar antibacterial activity for 2% glutaraldehyde and 0. Glutaraldehyde is approved by the fda for cold sterilization andor highlevel disinfection of heatsensitive critical and semicritical patient care items, and is the most commonly used cold sterile solution in dentistry. Reregistration eligibility decision for glutaraldehyde. A popular misconception is that used opa or glutaraldehyde is no longer biocidal read dangerous after its reuse date has passed or it has failed a mec test. Evaluation of three glutaraldehydebased disinfectants. Articles mechanism of glutaraldehyde disinfectants. Since the free chlorine is inactivated by light and air, disinfectant chlorine solutions are best made fresh before use. Glutaraldehyde solution is a liquid chemical sterilant and highlevel disinfectant.
Validation of microbial recovery from disinfectants. Glutaraldehyde solution sds msds sheet, suppliers and manufacturers represantative. It has a role as a crosslinking reagent, a disinfectant and a fixative. Kemsafe powder neutralizer for glutaraldehyde and opa disinfectant solutions glycine based formulation directions. Glutaraldehyde, sold under the brandname cidex and glutaral among others, is a disinfectant, medication, preservative, and fixative. Metricide opa plus solution provides high level disinfection through a broad spectrum of kill including tb, hepatitis a, hepatitis b, hiv1, and poliovirus 1. A 2% glutaraldehyde solution is activated by alkali for use as a broadspectrum disinfectant. However, it is also a protein fixative, therefore the surfaces soiled with protein based soils like blood must be precleaned with a detergent solution prior to their. Glutaraldehyde solution is a highlevel disinfectant when used. Similarly agents that are virucidal, fungicidal or sporicidal are agents capable of killing these organisms. Covid19 chemical disinfectant safety information page 2 of 6. Glutaraldehyde glut or 1,5pentanedial is one the most commonly used disinfectant ingredients from the family of aldehydes.
346 431 189 452 1260 1471 1531 969 852 1402 1364 1356 695 904 1632 373 1623 1238 448 869 860 476 988 1193 1464 1467 566 252 1230 1151 65 144 1069 33 788